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MT000703

UniProt Annotations

Entry Information

Gene Name	benzodiazepine receptor (peripheral) associated protein 1
Protein Entry	RIMB1_HUMAN
UniProt ID	O95153
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O95153-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=O95153-2; Sequence=VSP_009204; Note=No experimental confirmation available.; Name=3; IsoId=O95153-3; Sequence=VSP_009205; Note=No experimental confirmation available.;
Caution	PubMed:9915832 demonstrated interaction with BZRP but later PubMed:12435798 demonstrated in the rat ortholog that is not associated with BZRP in the brain. {ECO:0000305}.
Domain	The SH3 and proline-rich domain is required for the interaction with BZRP and the second SH3 domain mediates binding to a proline-rich motif in RIMS1 and RIMS2. {ECO:0000250}.
Interaction	O00555:CACNA1A; NbExp=2; IntAct=EBI-5915931, EBI-766279;
Sequence Caution	Sequence=BAA31587.2; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity	Belongs to the RIMBP family. {ECO:0000305}.
Similarity	Contains 3 fibronectin type-III domains. {ECO:0000255\|PROSITE-ProRule:PRU00316}.
Similarity	Contains 3 SH3 domains. {ECO:0000255\|PROSITE- ProRule:PRU00192}.
Subcellular Location	Cytoplasm {ECO:0000269\|PubMed:9915832}. Mitochondrion {ECO:0000269\|PubMed:9915832}. Note=Preferentially expressed in the mitochondria in the presence of BZRP.
Subunit	Interacts with RIMS1 and RIMS2 (By similarity). Interacts with BZRP. {ECO:0000250, ECO:0000269\|PubMed:9915832}.
Tissue Specificity	Predominantly expressed in brain, pituitary gland and thymus in adults. In adult brain, highest expression found in temporal lobe and the putamen, followed by amygdala, caudate nucleus, cerebral cortex, occipital and frontal lobe. A high expression level is also observed in fetal tissues like brain, heart, kidney and thymus. {ECO:0000269\|PubMed:9915832}.