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MT000706

UniProt Annotations

Entry Information

Gene Name	DEAD (Asp-Glu-Ala-Asp) box polypeptide 23
Protein Entry	DDX23_HUMAN
UniProt ID	Q9BUQ8
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BUQ8-1; Sequence=Displayed; Name=2; IsoId=Q9BUQ8-2; Sequence=VSP_056575, VSP_056576; Note=No experimental confirmation available.;
Catalytic Activity	ATP + H(2)O = ADP + phosphate.
Function	Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. {ECO:0000269\|PubMed:18425142}.
Ptm	In vitro phosphorylated by CLK1 and U1 snRNP-associated protein kinase. Phosphorylated by SRPK2 and this phosphorylation is required for its association with the tri-snRNP (U4/U6-U5 tri- small nuclear ribonucleoproteins) and subsequent spliceosomal B complex formation. {ECO:0000269\|PubMed:18425142, ECO:0000269\|PubMed:20068231, ECO:0000269\|PubMed:21406692, ECO:0000269\|PubMed:9409622}.
Similarity	Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily. {ECO:0000305}.
Similarity	Contains 1 helicase ATP-binding domain. {ECO:0000255\|PROSITE-ProRule:PRU00541}.
Similarity	Contains 1 helicase C-terminal domain. {ECO:0000255\|PROSITE-ProRule:PRU00542}.
Subcellular Location	Nucleus {ECO:0000269\|PubMed:20858735, ECO:0000269\|PubMed:9409622}.
Subunit	The phosphorylated form (by SRPK2) is a component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, WDR57, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2, SART1 and USP39. Identified in the spliceosome C complex. Interacts with ERBB4. {ECO:0000269\|PubMed:11991638, ECO:0000269\|PubMed:16723661, ECO:0000269\|PubMed:20858735, ECO:0000269\|PubMed:9409622}.