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MT000725

UniProt Annotations

Entry Information

Gene Name	ATP-binding cassette, sub-family G (WHITE), member 1
Protein Entry	ABCG1_HUMAN
UniProt ID	P45844
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=8; Comment=Additional isoforms seem to exist.; Name=1; IsoId=P45844-1; Sequence=Displayed; Name=2; Synonyms=J; IsoId=P45844-2; Sequence=VSP_000047, VSP_000051; Name=3; Synonyms=ABDE; IsoId=P45844-3; Sequence=VSP_000048, VSP_000051; Name=4; Synonyms=G; IsoId=P45844-4; Sequence=VSP_000051; Name=5; Synonyms=F; IsoId=P45844-5; Sequence=VSP_000049, VSP_000051; Name=6; Synonyms=HI; IsoId=P45844-6; Sequence=VSP_000046, VSP_000051; Name=7; Synonyms=C; IsoId=P45844-7; Sequence=VSP_000050, VSP_000051; Name=8; IsoId=P45844-8; Sequence=VSP_010718;
Function	Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages.
Induction	Strongly induced in monocyte-derived macrophages during cholesterol influx. Conversely, mRNA and protein expression are suppressed by lipid efflux. Induction is mediated by the liver X receptor/retinoid X receptor (LXR/RXR) pathway. Not induced by bacterial lipopolysaccharides (LPS). Repressed by ZNF202. {ECO:0000269\|PubMed:10639163, ECO:0000269\|PubMed:10799558, ECO:0000269\|PubMed:11279031, ECO:0000269\|PubMed:12032171}.
Interaction	Q9H172:ABCG4; NbExp=2; IntAct=EBI-8584087, EBI-8584118;
Miscellaneous	A protein of the expected size has been detected by antibody binding and Western blot in at least one of the analyzed tissues or cells. {ECO:0000305\|PubMed:22042635}.
Ptm	Palmitoylation at Cys-315 seems important for trafficking from the endoplasmic reticulum. {ECO:0000269\|PubMed:23388354}.
Sequence Caution	Sequence=AAC51098.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAK28841.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA95530.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB13728.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA62631.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAC00730.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Similarity	Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. {ECO:0000305}.
Similarity	Contains 1 ABC transmembrane type-2 domain. {ECO:0000305}.
Similarity	Contains 1 ABC transporter domain. {ECO:0000255\|PROSITE-ProRule:PRU00434}.
Subcellular Location	Mitochondrion {ECO:0000269\|PubMed:22042635}. Endoplasmic reticulum membrane {ECO:0000269\|PubMed:22042635}; Multi-pass membrane protein {ECO:0000269\|PubMed:22042635}. Golgi apparatus membrane {ECO:0000269\|PubMed:22042635}; Multi-pass membrane protein {ECO:0000269\|PubMed:22042635}. Note=Predominantly localized in the intracellular compartments mainly associated with the endoplasmic reticulum (ER) and Golgi membranes.
Subunit	May form heterodimers with several heterologous partners of the ABCG subfamily.
Tissue Specificity	Expressed in several tissues. Expressed in macrophages; expression is increased in macrophages from patients with Tangier disease. {ECO:0000269\|PubMed:11350058}.
Web Resource	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http://abcmutations.hegelab.org/proteinDetails?uniprot_id=P45844";