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MT000739

UniProt Annotations

Entry Information

Gene Name	caspase 8 associated protein 2
Protein Entry	C8AP2_HUMAN
UniProt ID	Q9UKL3
Species	Human

Comments

Comment type	Description
Function	Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF- kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269\|PubMed:12477726, ECO:0000269\|PubMed:15698540, ECO:0000269\|PubMed:17003125, ECO:0000269\|PubMed:17245429}.
Induction	By TNF which induces strong nuclear localization. {ECO:0000269\|PubMed:12477726}.
Interaction	Q14790:CASP8; NbExp=3; IntAct=EBI-2339650, EBI-78060; O75925:PIAS1; NbExp=4; IntAct=EBI-2339650, EBI-629434; P23497:SP100; NbExp=5; IntAct=EBI-2339650, EBI-751145; O15350-1:TP73; NbExp=2; IntAct=EBI-2339650, EBI-389619;
Sequence Caution	Sequence=AAH56685.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 364.; Evidence={ECO:0000305}; Sequence=BAA92067.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Subcellular Location	Cytoplasm. Nucleus. Nucleus, PML body. Mitochondrion. Note=Exported from the nucleus to the mitochondria upon FAS activation.
Subunit	Self-associates. Component of the death-inducing signaling complex (DISC) with CASP8, FADD and FAS. Interacts with NCOA2 and NCOA3. Interacts with SRRT. Interacts with TRAF2. Interacts with NPAT. Interacts (via SIM domains) with SUMO1 and SUMO2. Interacts with SP100; may negatively regulate CASP8AP2 export from the nucleus to the cytoplasm. {ECO:0000269\|PubMed:12477726, ECO:0000269\|PubMed:15698540, ECO:0000269\|PubMed:17003125, ECO:0000269\|PubMed:17245429, ECO:0000269\|PubMed:19546234, ECO:0000269\|PubMed:23086935}.