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MT000742

UniProt Annotations

Entry Information

Gene Name	acyl-CoA thioesterase 8
Protein Entry	ACOT8_HUMAN
UniProt ID	O14734
Species	Human

Comments

Comment type	Description
Catalytic Activity	Choloyl-CoA + H(2)O = cholate + CoA.
Function	Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May mediate Nef-induced down-regulation of CD4. Major thioesterase in peroxisomes. Competes with BAAT (Bile acid CoA: amino acid N- acyltransferase) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). Shows a preference for medium-length fatty acyl-CoAs (By similarity). May be involved in the metabolic regulation of peroxisome proliferation. {ECO:0000250, ECO:0000269\|PubMed:15194431}.
Induction	Regulated by peroxisome proliferator (such as Clofibrate), via the peroxisome proliferator-activated receptors (PPARs). {ECO:0000250}.
Interaction	P04601:nef (xeno); NbExp=5; IntAct=EBI-1237371, EBI-6164028;
Similarity	Belongs to the C/M/P thioester hydrolase family. {ECO:0000305}.
Subcellular Location	Peroxisome.
Subunit	Interacts with HIV-1 Nef. {ECO:0000269\|PubMed:9299485}.
Tissue Specificity	Detected in a T-cell line (at protein level). Ubiquitous. {ECO:0000269\|PubMed:9299485}.