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MT000759

UniProt Annotations

Entry Information

Gene Name	dehydrogenase/reductase (SDR family) member 2
Protein Entry	DHRS2_HUMAN
UniProt ID	Q13268
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q13268-1; Sequence=Displayed; Name=2; IsoId=Q13268-2; Sequence=VSP_038179;
Biophysicochemical Properties	Kinetic parameters: KM=0.3 mM for 1-Phenyl-1,2-propanedione {ECO:0000269\|PubMed:16685466}; KM=1.1 mM for 2,3-Heptanedione {ECO:0000269\|PubMed:16685466}; KM=0.8 mM for 3,4-Hexanedione {ECO:0000269\|PubMed:16685466}; Vmax=0.52 mmol/min/mg enzyme with 1-Phenyl-1,2-propanedione as substrate {ECO:0000269\|PubMed:16685466}; Vmax=0.64 mmol/min/mg enzyme with 2,3-Heptanedione as substrate {ECO:0000269\|PubMed:16685466}; Vmax=0.35 mmol/min/mg enzyme with 3,4-Hexanedione as substrate {ECO:0000269\|PubMed:16685466};
Function	Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2- propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21. {ECO:0000269\|PubMed:16685466, ECO:0000269\|PubMed:20547751}.
Induction	Up-regulated by IL4 and CSF2 in monocytes/macrophages. Down-regulated by bacterial lipopolysaccharides (LPS) and TNF in monocytice-derived dendritic cells. Up-regulated by MYB. {ECO:0000269\|PubMed:11944995}.
Similarity	Belongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.
Subcellular Location	Mitochondrion matrix. Nucleus. Note=A minor fraction of the protein is translocated from the mitochondria to the nucleus, after cleavage of the targeting signal.
Subunit	Directly interacts with MDM2; this interaction occurs in the nucleus and does not target DHRS2 to degradation. {ECO:0000269\|PubMed:20547751}.
Tissue Specificity	Widely expressed, with highest levels in liver and kidney, followed by heart, spleen, skeletal muscle and placenta. In hemopoietic cells, expressed in dendritic cells, but not in monocytes, macrophages, granulocytes, nor in B and T lymphocytes. {ECO:0000269\|PubMed:11944995}.