MitoProteome Database

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MT000760

UniProt Annotations

Entry Information

Gene Name	coenzyme Q7 homolog, ubiquinone (yeast)
Protein Entry	COQ7_HUMAN
UniProt ID	Q99807
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q99807-1; Sequence=Displayed; Name=2; IsoId=Q99807-2; Sequence=VSP_039068;
Cofactor	Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000250}; Note=Binds 2 iron ions per subunit. {ECO:0000250};
Function	Involved in lifespan determination in ubiquinone- independent manner. Involved in ubiquinone biosynthesis. Potential central metabolic regulator (By similarity). {ECO:0000250}.
Pathway	Cofactor biosynthesis; ubiquinone biosynthesis.
Similarity	Belongs to the COQ7 family. {ECO:0000305}.
Subcellular Location	Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Note=Synthesized as a preprotein that is imported into the mitochondrial matrix, where the sequence is cleaved off and the mature protein becomes loosely associated with the inner membrane. {ECO:0000250}.
Subunit	Interacts with ADCK4 and COQ6. {ECO:0000269\|PubMed:24270420}.
Tissue Specificity	Expressed dominantly in heart and skeletal muscle.