MitoProteome Database

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MT000766

UniProt Annotations

Entry Information

Gene Name	A kinase (PRKA) anchor protein 8
Protein Entry	AKAP8_HUMAN
UniProt ID	O43823
Species	Human

Comments

Comment type	Description
Function	Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II).
Similarity	Belongs to the AKAP95 family. {ECO:0000305}.
Similarity	Contains 2 C2H2 AKAP95-type zinc fingers. {ECO:0000305}.
Subcellular Location	Nucleus matrix. Note=Associated with the nuclear matrix. Redistributed and detached from condensed chromatin during mitosis.
Subunit	Binds to dimeric RII-alpha regulatory subunit of PKA during mitosis. Interacts (via C-terminus) with FIGN (By similarity). {ECO:0000250}.
Tissue Specificity	Highly expressed in heart, liver, skeletal muscle, kidney and pancreas.