MitoProteome Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins

MT000771

UniProt Annotations

Entry Information

Gene Name	ATP-binding cassette, sub-family A (ABC1), member 8
Protein Entry	ABCA8_HUMAN
UniProt ID	O94911
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O94911-1; Sequence=Displayed; Name=2; IsoId=O94911-2; Sequence=VSP_020703; Note=No experimental confirmation available.; Name=3; IsoId=O94911-3; Sequence=VSP_053440; Note=No experimental confirmation available.;
Biophysicochemical Properties	Kinetic parameters: KM=30.4 uM for estradiol-beta-glucuronide {ECO:0000269\|PubMed:12379217}; KM=0.1 uM for LTC4 {ECO:0000269\|PubMed:12379217}; KM=10.3 uM for taurochlorate {ECO:0000269\|PubMed:12379217}; KM=5.0 uM for PAH {ECO:0000269\|PubMed:12379217}; KM=0.5 uM for estrone sulfate {ECO:0000269\|PubMed:12379217}; KM=0.4 uM for ochratoxin A {ECO:0000269\|PubMed:12379217};
Function	ATP-dependent lipophilic drug transporter. {ECO:0000269\|PubMed:12379217}.
Sequence Caution	Sequence=BAA74845.2; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity	Belongs to the ABC transporter superfamily. ABCA family. {ECO:0000305}.
Similarity	Contains 2 ABC transporter domains. {ECO:0000255\|PROSITE-ProRule:PRU00434}.
Subcellular Location	Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue Specificity	Widely expressed with higher expression in heart, skeletal muscle and liver. {ECO:0000269\|PubMed:12379217}.
Web Resource	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http://abcmutations.hegelab.org/proteinDetails?uniprot_id=O94911";