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MT000791

UniProt Annotations

Entry Information

Gene Name	anterior gradient 2
Protein Entry	AGR2_HUMAN
UniProt ID	O95994
Species	Human

Comments

Comment type	Description
Function	Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. {ECO:0000250, ECO:0000269\|PubMed:18199544}.
Similarity	Belongs to the AGR family. {ECO:0000305}.
Subcellular Location	Secreted {ECO:0000269\|PubMed:15834940}. Endoplasmic reticulum {ECO:0000250}.
Subunit	Interacts with LYPD3 and DAG1 (alphaDAG1). Interacts with MUC2; disulfide-linked. {ECO:0000269\|PubMed:12592373, ECO:0000269\|PubMed:19359471}.
Tissue Specificity	Expressed strongly in trachea, lung, stomach, colon, prostate and small intestine. Expressed weakly in pituitary gland, salivary gland, mammary gland, bladder, appendix, ovary, fetal lung, uterus, pancreas, kidney, fetal kidney, testis, placenta, thyroid gland and in estrogen receptor (ER)-positive breast cancer cell lines. {ECO:0000269\|PubMed:9790916}.