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MT000816

UniProt Annotations

Entry Information

Gene Name	bromodomain containing 8
Protein Entry	BRD8_HUMAN
UniProt ID	Q9H0E9
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9H0E9-1; Sequence=Displayed; Name=2; IsoId=Q9H0E9-2; Sequence=VSP_012880, VSP_012883, VSP_012884; Note=Contains a phosphothreonine at position 264. Contains a phosphoserine at position 268. Contains a phosphoserine at position 284. Contains a phosphoserine at position 924.; Name=3; IsoId=Q9H0E9-3; Sequence=VSP_012879, VSP_012880, VSP_012881, VSP_012882, VSP_012883, VSP_012884; Note=Contains a phosphothreonine at position 124. Contains a phosphoserine at position 128. Contains a phosphoserine at position 144.; Name=4; IsoId=Q9H0E9-4; Sequence=VSP_012880, VSP_023187, VSP_023188, VSP_023189, VSP_023190, VSP_023191; Note=Contains a phosphothreonine at position 264. Contains a phosphoserine at position 268. Contains a phosphoserine at position 284.;
Caution	It is uncertain whether Met-1 or Met-32 is the initiator. {ECO:0000305}.
Function	May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1- like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. {ECO:0000269\|PubMed:10517671, ECO:0000269\|PubMed:14966270, ECO:0000269\|PubMed:24463511}.
Sequence Caution	Sequence=AAB87858.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH08039.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH08076.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA63925.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Similarity	Contains 2 bromo domains. {ECO:0000255\|PROSITE- ProRule:PRU00035}.
Subcellular Location	Nucleus.
Subunit	Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. BRD8 isoform 2 interacts with RXRA/NR2B1 and THRB/ERBA2 (By similarity). Component of a SWR1-like complex. {ECO:0000250, ECO:0000269\|PubMed:10517671, ECO:0000269\|PubMed:14966270, ECO:0000269\|PubMed:24463511, ECO:0000269\|PubMed:9368056}.
Tissue Specificity	Expressed in adipose tissue, brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle. {ECO:0000269\|PubMed:8611617}.