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MitoProteome Human Mitochondrial Protein Database
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Related Proteins
MT000852
UniProt Annotations
Entry Information
Gene Name
acyl-CoA thioesterase 7
Protein Entry
BACH_HUMAN
UniProt ID
O00154
Species
Human
Comments
Comment type
Description
Alternative Products
Event=Alternative splicing; Named isoforms=7; Name=1; Synonyms=B, HBACHb; IsoId=O00154-1; Sequence=Displayed; Name=2; Synonyms=A-X, hBACHa-X; IsoId=O00154-2; Sequence=VSP_000152, VSP_000155, VSP_000156; Name=3; Synonyms=A-Xi, hBACHa-Xi; IsoId=O00154-3; Sequence=VSP_000152, VSP_000154; Name=4; Synonyms=A, hBACHa; IsoId=O00154-4; Sequence=VSP_000152; Note=Major isoform.; Name=5; Synonyms=C, hBACHc; IsoId=O00154-5; Sequence=VSP_000151; Name=6; Synonyms=D, hBACHd; IsoId=O00154-6; Sequence=VSP_000153; Name=7; IsoId=O00154-7; Sequence=VSP_047094;
Catalytic Activity
Palmitoyl-CoA + H(2)O = CoA + palmitate.
Domain
Both hydrolase domains are required for efficient activity. {ECO:0000250}.
Function
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May play an important physiological function in brain. May play a regulatory role by modulating the cellular levels of fatty acyl- CoA ligands for certain transcription factors as well as the substrates for fatty acid metabolizing enzymes, contributing to lipid homeostasis. Has broad specificity, active towards fatty acyl-CoAs with chain-lengths of C8-C18. Has a maximal activity toward palmitoyl-CoA.
Sequence Caution
Sequence=AAB61211.1; Type=Frameshift; Positions=371; Evidence={ECO:0000305}; Sequence=AAH17365.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI19435.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI19774.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity
Contains 2 acyl coenzyme A hydrolase domains. {ECO:0000305}.
Subcellular Location
Isoform 1: Mitochondrion.
Subcellular Location
Isoform 4: Cytoplasm.
Subcellular Location
Isoform 5: Mitochondrion.
Subcellular Location
Isoform 6: Cytoplasm.
Subunit
Homohexamer. {ECO:0000250}.
Tissue Specificity
Isoform 4 is expressed exclusively in brain. {ECO:0000269|PubMed:12435388}.
MitoProteome Human Mitochondrial Protein Database
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