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MT000861

UniProt Annotations

Entry Information

Gene Name	DEAH (Asp-Glu-Ala-His) box helicase 30
Protein Entry	DHX30_HUMAN
UniProt ID	Q7L2E3
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=3; Comment=Additional isoforms seem to exist.; Name=1; IsoId=Q7L2E3-1; Sequence=Displayed; Name=2; IsoId=Q7L2E3-2; Sequence=VSP_022118; Note=Contains a phosphoserine at position 15.; Name=3; IsoId=Q7L2E3-3; Sequence=VSP_036891, VSP_036892;
Catalytic Activity	ATP + H(2)O = ADP + phosphate.
Function	Required for optimal function of the zinc-finger antiviral protein ZC3HAV1 (By similarity). Associates with mitochondrial DNA. {ECO:0000250, ECO:0000269\|PubMed:16825194}.
Interaction	P50750:CDK9; NbExp=5; IntAct=EBI-1211456, EBI-1383449; Q96C10:DHX58; NbExp=2; IntAct=EBI-1211456, EBI-744193; P19525:EIF2AK2; NbExp=3; IntAct=EBI-1211456, EBI-640775; Q13547:HDAC1; NbExp=3; IntAct=EBI-1211456, EBI-301834; O15379:HDAC3; NbExp=3; IntAct=EBI-1211456, EBI-607682; Q9BQG0:MYBBP1A; NbExp=3; IntAct=EBI-1211456, EBI-676973; O75376:NCOR1; NbExp=3; IntAct=EBI-1211456, EBI-347233; Q9Y5X4:NR2E3; NbExp=5; IntAct=EBI-1211456, EBI-7216962; Q9Y6K5:OAS3; NbExp=2; IntAct=EBI-1211456, EBI-6115729; Q09028:RBBP4; NbExp=3; IntAct=EBI-1211456, EBI-620823; Q16576:RBBP7; NbExp=4; IntAct=EBI-1211456, EBI-352227; P28749:RBL1; NbExp=4; IntAct=EBI-1211456, EBI-971402; Q96ST3:SIN3A; NbExp=3; IntAct=EBI-1211456, EBI-347218; Q12788:TBL3; NbExp=5; IntAct=EBI-1211456, EBI-715766;
Ptm	Isoform 2 is phosphorylated on Ser-15.
Sequence Caution	Sequence=BAA74913.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA92071.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};
Similarity	Belongs to the DEAD box helicase family. DEAH subfamily. {ECO:0000305}.
Similarity	Contains 1 DRBM (double-stranded RNA-binding) domain. {ECO:0000305}.
Similarity	Contains 1 helicase ATP-binding domain. {ECO:0000255\|PROSITE-ProRule:PRU00541}.
Similarity	Contains 1 helicase C-terminal domain. {ECO:0000255\|PROSITE-ProRule:PRU00542}.
Subcellular Location	Isoform 1: Cytoplasm.
Subcellular Location	Isoform 2: Cytoplasm.
Subcellular Location	Mitochondrion. Cytoplasm {ECO:0000305}. Mitochondrion matrix, mitochondrion nucleoid.
Subunit	Identified in a complex with TFAM and SSBP1. Interacts with AGO1 and AGO2. Interacts (via N-terminus) with ZC3HAV1 (via N-terminal domain) in an RNA-independent manner (By similarity). {ECO:0000250}.