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MT000877

UniProt Annotations

Entry Information

Gene Name	ATP/GTP binding protein 1
Protein Entry	CBPC1_HUMAN
UniProt ID	Q9UPW5
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9UPW5-1; Sequence=Displayed; Name=2; IsoId=Q9UPW5-2; Sequence=VSP_029044; Name=3; IsoId=Q9UPW5-3; Sequence=VSP_040422, VSP_029044; Note=No experimental confirmation available.;
Cofactor	Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 1 zinc ion per subunit. {ECO:0000250};
Function	Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. {ECO:0000250\|UniProtKB:Q641K1}.
Sequence Caution	Sequence=BAA82987.2; Type=Frameshift; Positions=10; Evidence={ECO:0000305}; Sequence=BAB14100.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14505.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG61460.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH56222.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW62697.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Similarity	Belongs to the peptidase M14 family. {ECO:0000305}.
Subcellular Location	Cytoplasm {ECO:0000269\|PubMed:23085998}. Cytoplasm, cytosol {ECO:0000250\|UniProtKB:Q641K1}. Nucleus {ECO:0000269\|PubMed:23085998}. Mitochondrion {ECO:0000250\|UniProtKB:Q641K1}. Note=Localizes in both the cytoplasm and nuclei of interphase and dividing cells. {ECO:0000269\|PubMed:23085998}.
Subunit	Interacts with MYLK. {ECO:0000250}.