MitoProteome Database

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MT000889

UniProt Annotations

Entry Information

Gene Name	ATP-binding cassette, sub-family B (MDR/TAP), member 10
Protein Entry	ABCBA_HUMAN
UniProt ID	Q9NRK6
Species	Human

Comments

Comment type	Description
Function	May mediate critical mitochondrial transport functions related to heme biosynthesis. {ECO:0000250}.
Similarity	Belongs to the ABC transporter superfamily. ABCB family. Mitochondrial peptide exporter (TC 3.A.1.212) subfamily. {ECO:0000305}.
Similarity	Contains 1 ABC transmembrane type-1 domain. {ECO:0000255\|PROSITE-ProRule:PRU00441}.
Similarity	Contains 1 ABC transporter domain. {ECO:0000255\|PROSITE-ProRule:PRU00434}.
Subcellular Location	Mitochondrion inner membrane; Multi-pass membrane protein.
Subunit	Homodimer or homooligomer. {ECO:0000269\|PubMed:15215243, ECO:0000269\|PubMed:23716676}.
Tissue Specificity	Ubiquitous. Highly expressed in bone marrow, expressed at intermediate to high levels in skeletal muscle, small intestine, thyroid, heart, brain, placenta, liver, pancreas, prostate, testis, ovary, leukocyte, stomach, spinal cord, lymph node, trachea and adrenal gland, and low levels are found in lung, kidney, spleen, thymus and colon.
Web Resource	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http://abcmutations.hegelab.org/proteinDetails?uniprot_id=Q9NRK6";