MitoProteome Database

MT000969

Record overview

MITO ID	MT000969
Gene ID	27301
Species	Homo sapiens (Human)
Gene Name	APEX nuclease (apurinic/apyrimidinic endonuclease) 2
Gene Symbol	APEX2
Synonyms	APE2; XTH2; ZGRF2; APEXL2;
Alternate names	DNA-(apurinic or apyrimidinic site) lyase 2; AP endonuclease 2; AP endonuclease XTH2; zinc finger, GRF-type containing 2; apurinic/apyrimidinic endonuclease-like 2;
Chromosome	X
Map Location	Xp11.21
EC Number	3.1.-.-
Summary	Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]
Orthologs	View orthologs and multiple alignments for APEX2

Proteins

DNA-(apurinic or apyrimidinic site) lyase 2 isoform 1

Refseq ID:	NP_055296
Protein GI:	18375507
UniProt ID:	Q9UBZ4
mRNA ID:	NM_014481
Length:	518
RefSeq Status:

MLRVVSWNINGIRRPLQGVANQEPSNCAAVAVGRILDELDADIVCLQETKVTRDALTEPLAIVEGYNSYFSFSRNRSGYSGVATFCKDNATPVAAEEGLS
GLFATQNGDVGCYGNMDEFTQEELRALDSEGRALLTQHKIRTWEGKEKTLTLINVYCPHADPGRPERLVFKMRFYRLLQIRAEALLAAGSHVIILGDLNT
AHRPIDHWDAVNLECFEEDPGRKWMDSLLSNLGCQSASHVGPFIDSYRCFQPKQEGAFTCWSAVTGARHLNYGSRLDYVLGDRTLVIDTFQASFLLPEVM
GSDHCPVGAVLSVSSVPAKQCPPLCTRFLPEFAGTQLKILRFLVPLEQSPVLEQSTLQHNNQTRVQTCQNKAQVRSTRPQPSQVGSSRGQKNLKSYFQPS
PSCPQASPDIELPSLPLMSALMTPKTPEEKAVAKVVKGQAKTSEAKDEKELRTSFWKSVLAGPLRTPLCGGHREPCVMRTVKKPGPNLGRRFYMCARPRG
PPTDPSSRCNFFLWSRPS

DNA-(apurinic or apyrimidinic site) lyase 2 isoform 2

Refseq ID:	NP_001258677
Protein GI:	414144888
UniProt ID:	B4DWI9
mRNA ID:	NM_001271748
Length:	347
RefSeq Status:

`MRFYRLLQIRAEALLAAGSHVIILGDLNTAHRPIDHWDAVNLECFEEDPGRKWMDSLLSNLGCQSASHVGPFIDSYRCFQPKQEGAFTCWSAVTGARHLN YGSRLDYVLGDRTLVIDTFQASFLLPEVMGSDHCPVGAVLSVSSVPAKQCPPLCTRFLPEFAGTQLKILRFLVPLEQSPVLEQSTLQHNNQTRVQTCQNK AQVRSTRPQPSQVGSSRGQKNLKSYFQPSPSCPQASPDIELPSLPLMSALMTPKTPEEKAVAKVVKGQAKTSEAKDEKELRTSFWKSVLAGPLRTPLCGG HREPCVMRTVKKPGPNLGRRFYMCARPRGPPTDPSSRCNFFLWSRPS`