MitoProteome Database

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MT000990

UniProt Annotations

Entry Information

Gene Name	DnaJ (Hsp40) homolog, subfamily C, member 15
Protein Entry	DJC15_HUMAN
UniProt ID	Q9Y5T4
Species	Human

Comments

Comment type	Description
Disease	Note=Absent or down-regulated in many advanced cases of ovarian adenocarcinoma, due to hypermethylation and allelic loss. Loss of expression correlates with increased resistance to antineoplastic drugs, such as cisplatin.
Function	Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9. {ECO:0000250, ECO:0000269\|PubMed:23263864}.
Similarity	Contains 1 J domain. {ECO:0000255\|PROSITE- ProRule:PRU00286}.
Subcellular Location	Mitochondrion inner membrane {ECO:0000269\|PubMed:23263864, ECO:0000269\|PubMed:23530063}; Single-pass membrane protein {ECO:0000269\|PubMed:23263864, ECO:0000269\|PubMed:23530063}.
Subunit	Interacts with the TIM23 complex. Directly interacts with PAM16/MAGMAS; this interaction counteracts DNAJC15-dependent stimulation of HSPA9 ATPase activity. Associates with complex I of the mitochondrial electron transfer chain; this interaction may interfere with the formation of supercomplexes that facilitate the transfer of electrons between complexes (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed at highest levels in heart, followed by liver and kidney. {ECO:0000269\|PubMed:11358853, ECO:0000269\|PubMed:23530063}.