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MT001005

UniProt Annotations

Entry Information

Gene Name	adenylate kinase 3
Protein Entry	Q7Z4Y4_HUMAN
UniProt ID	Q7Z4Y4
Species	Human

Comments

Comment type	Description
Catalytic Activity	NTP + AMP = NDP + ADP. {ECO:0000256\|HAMAP- Rule:MF_03169}.
Domain	Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis. {ECO:0000256\|HAMAP- Rule:MF_03169}.
Function	Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. {ECO:0000256\|HAMAP-Rule:MF_03169}.
Similarity	Belongs to the adenylate kinase family. AK3 subfamily. {ECO:0000256\|HAMAP-Rule:MF_03169}.
Similarity	Belongs to the adenylate kinase family. {ECO:0000256\|RuleBase:RU003330}.
Subcellular Location	Mitochondrion matrix {ECO:0000256\|HAMAP- Rule:MF_03169}.
Subunit	Monomer. {ECO:0000256\|HAMAP-Rule:MF_03169}.