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MT001039

UniProt Annotations

Entry Information

Gene Name	acid phosphatase 6, lysophosphatidic
Protein Entry	PPA6_HUMAN
UniProt ID	Q9NPH0
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NPH0-1; Sequence=Displayed; Name=2; IsoId=Q9NPH0-2; Sequence=VSP_014121, VSP_014122; Note=No experimental confirmation available.;
Catalytic Activity	A phosphate monoester + H(2)O = an alcohol + phosphate. {ECO:0000269\|PubMed:23807634}.
Caution	It is uncertain whether Met-1 or Met-8 is the initiator. {ECO:0000305}.
Caution	Was originally reported to be located in the mitochondrion, but the evidence seems to be weak and contradictory with the presence of a cleaved signal sequence. {ECO:0000305\|PubMed:10506173}.
Function	Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid. {ECO:0000269\|PubMed:10506173, ECO:0000269\|PubMed:23807634}.
Induction	Induced with the differentiation from myoblast to myotube. {ECO:0000269\|PubMed:10506173}.
Sequence Caution	Sequence=BAA89311.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD92485.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Similarity	Belongs to the histidine acid phosphatase family. {ECO:0000305}.
Subcellular Location	Mitochondrion {ECO:0000269\|PubMed:10506173}.
Subunit	Monomer. {ECO:0000269\|PubMed:23807634}.
Tissue Specificity	Highly expressed in kidney, heart, small intestine, muscle, liver, prostate, testis, ovary and weakly expressed in thymus and colon. {ECO:0000269\|PubMed:10506173, ECO:0000269\|PubMed:12010880}.