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MT001048

UniProt Annotations

Entry Information

Gene Name	DnaJ (Hsp40) homolog, subfamily C, member 27
Protein Entry	DJC27_HUMAN
UniProt ID	Q9NZQ0
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9NZQ0-1; Sequence=Displayed; Name=2; IsoId=Q9NZQ0-2; Sequence=VSP_033409, VSP_033410; Name=3; IsoId=Q9NZQ0-3; Sequence=VSP_033411, VSP_033412;
Function	GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. {ECO:0000250\|UniProtKB:Q8CFP6}.
Miscellaneous	DNAJC27/RBJ knockdown in several colorectal cancer cell lines is correlated to inhibition of MEK/ERK activation, cell proliferation, colony formation and in vivo tumor growth. {ECO:0000269\|PubMed:24746703}.
Similarity	Belongs to the small GTPase superfamily. Rab family. {ECO:0000305}.
Similarity	Contains 1 J domain. {ECO:0000255\|PROSITE- ProRule:PRU00286}.
Subcellular Location	Nucleus {ECO:0000250\|UniProtKB:Q8CFP6}.
Subunit	Interacts directly with MAPK1 (wild-type and kinase- deficient forms). Interacts directly (in GTP-bound form) with MAP2K1 (wild-type and kinase-deficient forms). {ECO:0000250\|UniProtKB:Q8CFP6}.
Tissue Specificity	Overexpressed in gastrointestinal cancers; expression correlates with later tumor-node-metastasis stages of colorectal cancers. {ECO:0000269\|PubMed:24746703}.