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MT001070

UniProt Annotations

Entry Information

Gene Name	acyl-CoA synthetase long-chain family member 5
Protein Entry	ACSL5_HUMAN
UniProt ID	Q9ULC5
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=ACSL5b, ACSL5-fl; IsoId=Q9ULC5-1; Sequence=Displayed; Note=Localize in mitochondrion and endoplasmic reticulum.; Name=2; Synonyms=ACSL5a; IsoId=Q9ULC5-3; Sequence=VSP_037947; Note=Contains a phosphoserine at position 32.; Name=3; Synonyms=ACSL5delta20; IsoId=Q9ULC5-4; Sequence=VSP_038233; Note=Localize in mitochondrion and endoplasmic reticulum.;
Biophysicochemical Properties	Kinetic parameters: KM=0.11 uM for palmitic acid (isoform 1 at pH 7.5) {ECO:0000269\|PubMed:17681178}; KM=0.38 uM for palmitic acid (isoform 1 at pH 9.5) {ECO:0000269\|PubMed:17681178}; KM=0.04 uM for palmitic acid (isoform 3 at pH 7.5) {ECO:0000269\|PubMed:17681178}; KM=0.15 uM for palmitic acid (isoform 3 at pH 8.5) {ECO:0000269\|PubMed:17681178}; pH dependence: Optimum pH is 9.5 (isoform 1), 7.5-8.5 (isoform 3). {ECO:0000269\|PubMed:17681178};
Catalytic Activity	ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.
Cofactor	Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
Function	Acyl-CoA synthetases (ACSL) activate long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells. {ECO:0000250, ECO:0000269\|PubMed:17681178, ECO:0000269\|PubMed:18806831, ECO:0000269\|PubMed:19459852}.
Sequence Caution	Sequence=BAA85979.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA86054.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Similarity	Belongs to the ATP-dependent AMP-binding enzyme family. {ECO:0000305}.
Subcellular Location	Mitochondrion. Endoplasmic reticulum. Mitochondrion outer membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}.