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MT001071

UniProt Annotations

Entry Information

Gene Name	cytochrome b5 reductase 1
Protein Entry	NB5R1_HUMAN
UniProt ID	Q9UHQ9
Species	Human

Comments

Comment type	Description
Catalytic Activity	NADH + 2 ferricytochrome b5 = NAD(+) + H(+) + 2 ferrocytochrome b5.
Cofactor	Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
Function	NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction. {ECO:0000250}.
Sequence Caution	Sequence=AAC72953.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI27946.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity	Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. {ECO:0000305}.
Similarity	Contains 1 FAD-binding FR-type domain. {ECO:0000255\|PROSITE-ProRule:PRU00716}.
Subcellular Location	Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Tissue Specificity	Widely expressed. {ECO:0000269\|PubMed:10611283}.