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MT001085

UniProt Annotations

Entry Information

Gene Name	DEAH (Asp-Glu-Ala-His) box polypeptide 29
Protein Entry	DHX29_HUMAN
UniProt ID	Q7Z478
Species	Human

Comments

Comment type	Description
Catalytic Activity	ATP + H(2)O = ADP + phosphate.
Function	ATP-binding RNA helicase involved in translation initiation. Part of the 43S preinitiation complex that is required for efficient initiation on mammalian mRNAs with structured 5'- UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity. {ECO:0000269\|PubMed:19109895, ECO:0000269\|PubMed:23706745}.
Similarity	Belongs to the DEAD box helicase family. DEAH subfamily. {ECO:0000305}.
Similarity	Contains 1 helicase ATP-binding domain. {ECO:0000255\|PROSITE-ProRule:PRU00541}.
Similarity	Contains 1 helicase C-terminal domain. {ECO:0000255\|PROSITE-ProRule:PRU00542}.
Subcellular Location	Cytoplasm {ECO:0000305}.
Subunit	Part of the 43S preinitiation complex that contains at least Met-tRNA, EIF1, EIF1A (EIF1AX or EIF1AY), EIF2S1, EIF2S2, EIF2S3, EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L, EIF3M, DHX29 and the 40S ribosomal subunit. {ECO:0000269\|PubMed:23706745}.