MitoProteome Database

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MT001093

UniProt Annotations

Entry Information

Gene Name	cardiolipin synthase 1
Protein Entry	CRLS1_HUMAN
UniProt ID	Q9UJA2
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UJA2-1; Sequence=Displayed; Name=2; IsoId=Q9UJA2-2; Sequence=VSP_041398, VSP_041399; Note=No experimental confirmation available.;
Catalytic Activity	2 Phosphatidylglycerol = diphosphatidylglycerol + glycerol.
Function	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. {ECO:0000269\|PubMed:16547353, ECO:0000269\|PubMed:16678169}.
Similarity	Belongs to the CDP-alcohol phosphatidyltransferase class-I family. {ECO:0000305}.
Subcellular Location	Mitochondrion inner membrane {ECO:0000269\|PubMed:16547353}; Multi-pass membrane protein {ECO:0000269\|PubMed:16547353}.
Tissue Specificity	Highly expressed in tissues such as heart, skeletal muscle and liver. {ECO:0000269\|PubMed:16547353}.