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MT001103

UniProt Annotations

Entry Information

Gene Name	ADP-ribosylhydrolase like 2
Protein Entry	ARHL2_HUMAN
UniProt ID	Q9NX46
Species	Human

Comments

Comment type	Description
Catalytic Activity	Hydrolyzes poly(ADP-D-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-D- ribose. {ECO:0000269\|PubMed:22433848}.
Cofactor	Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269\|PubMed:16278211}; Note=Binds 2 magnesium ions per subunit. {ECO:0000269\|PubMed:16278211};
Enzyme Regulation	Activity is enhanced by magnesium. {ECO:0000269\|PubMed:16278211}.
Function	Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells. Generates ADP-ribose from poly-(ADP-ribose), but does not hydrolyze ADP- ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds. Due to catalytic inactivity of PARG mitochondrial isoforms, ARH3 is the only PAR hydrolyzing enzyme in mitochondria. {ECO:0000269\|PubMed:16278211}.
Sequence Caution	Sequence=AAK14922.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};
Similarity	Belongs to the ADP-ribosylglycohydrolase family. {ECO:0000305}.
Subcellular Location	Cytoplasm. Mitochondrion matrix. Nucleus.
Subunit	Monomer. {ECO:0000250}.
Tissue Specificity	Ubiquitous. {ECO:0000269\|PubMed:16278211}.