MitoProteome Database

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MT001121

UniProt Annotations

Entry Information

Gene Name	coiled-coil domain containing 109B
Protein Entry	MCUB_HUMAN
UniProt ID	Q9NWR8
Species	Human

Comments

Comment type	Description
Function	Negatively regulates the activity of MCU, the mitochondrial inner membrane calcium uniporter, and thereby modulates calcium uptake into the mitochondrion. Does not form functional calcium channels by itself. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. {ECO:0000250\|UniProtKB:Q810S1}.
Sequence Caution	Sequence=AAH02633.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91309.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity	Belongs to the MCU (TC 1.A.77) family. {ECO:0000305}.
Subcellular Location	Mitochondrion inner membrane {ECO:0000269\|PubMed:24231807}; Multi-pass membrane protein {ECO:0000269\|PubMed:24231807}.
Subunit	Heterotetramer with MCU; this reduces MCU channel activity. Homooligomer (By similarity). Component of the uniplex complex, composed of MCU, MCUB, MICU1, MICU2 and EMRE/SMDT1. {ECO:0000250\|UniProtKB:Q810S1, ECO:0000269\|PubMed:24231807}.