MitoProteome Database

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MT001131

UniProt Annotations

Entry Information

Gene Name	arginine and glutamate rich 1
Protein Entry	ARGL1_HUMAN
UniProt ID	Q9NWB6
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9NWB6-1; Sequence=Displayed; Name=2; IsoId=Q9NWB6-2; Sequence=VSP_025674; Note=No experimental confirmation available.; Name=3; IsoId=Q9NWB6-3; Sequence=VSP_053685, VSP_025674; Note=No experimental confirmation available.;
Function	Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1. {ECO:0000269\|PubMed:21454576}.
Interaction	P78362:SRPK2; NbExp=2; IntAct=EBI-2808785, EBI-593303;
Sequence Caution	Sequence=CAI13166.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Similarity	Belongs to the UPF0430 family. {ECO:0000305}.
Subcellular Location	Nucleus {ECO:0000269\|PubMed:21454576}. Note=Recruited, in an estrogen-dependent manner, to ESR1 target gene promoters. Colocalizes with MED1.
Subunit	Directly interacts with MED1. {ECO:0000269\|PubMed:21454576}.