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MT001173

UniProt Annotations

Entry Information

Gene Name	carbohydrate kinase domain containing
Protein Entry	NNRD_HUMAN
UniProt ID	Q8IW45
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8IW45-1; Sequence=Displayed; Name=2; IsoId=Q8IW45-2; Sequence=VSP_033830; Name=3; IsoId=Q8IW45-3; Sequence=VSP_033829; Name=4; IsoId=Q8IW45-4; Sequence=VSP_042012; Note=No experimental confirmation available.;
Catalytic Activity	ATP + (6S)-6-beta-hydroxy-1,4,5,6- tetrahydronicotinamide-adenine dinucleotide = ADP + phosphate + NADH. {ECO:0000255\|HAMAP-Rule:MF_03157}.
Catalytic Activity	ATP + (6S)-6-beta-hydroxy-1,4,5,6- tetrahydronicotinamide-adenine dinucleotide phosphate = ADP + phosphate + NADPH.
Cofactor	Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255\|HAMAP-Rule:MF_03157};
Function	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. {ECO:0000255\|HAMAP-Rule:MF_03157}.
Similarity	Belongs to the NnrD/CARKD family. {ECO:0000255\|HAMAP- Rule:MF_03157}.
Similarity	Contains 1 YjeF C-terminal domain. {ECO:0000255\|HAMAP- Rule:MF_03157}.
Subcellular Location	Mitochondrion {ECO:0000255\|HAMAP- Rule:MF_03157}.