MitoProteome Database

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MT001174

UniProt Annotations

Entry Information

Gene Name	cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae)
Protein Entry	COA1_HUMAN
UniProt ID	Q9GZY4
Species	Human

Comments

Comment type	Description
Function	Component of some MITRAC complex, a cytochrome c oxidase (COX) assembly intermediate complex that regulates COX assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for assembly of mitochondrial respiratory chain complex I and complex IV. {ECO:0000269\|PubMed:23260140}.
Similarity	Belongs to the COA1 family. {ECO:0000305}.
Subcellular Location	Mitochondrion inner membrane {ECO:0000269\|PubMed:22356826, ECO:0000269\|PubMed:23260140}; Single-pass membrane protein {ECO:0000269\|PubMed:22356826, ECO:0000269\|PubMed:23260140}.
Subunit	Interacts with COX17 and COA6. Component of some MITRAC complex. {ECO:0000269\|PubMed:22356826, ECO:0000269\|PubMed:23260140}.