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MT001179

UniProt Annotations

Entry Information

Gene Name	ArfGAP with dual PH domains 2
Protein Entry	ADAP2_HUMAN
UniProt ID	Q9NPF8
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NPF8-1; Sequence=Displayed; Name=2; IsoId=Q9NPF8-2; Sequence=VSP_011180; Note=May be due to a competing acceptor splice site. No experimental confirmation available.;
Function	GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5- trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity. {ECO:0000269\|PubMed:14690521, ECO:0000305}.
Interaction	Q9Y6K9:IKBKG; NbExp=2; IntAct=EBI-718895, EBI-81279;
Similarity	Contains 1 Arf-GAP domain. {ECO:0000255\|PROSITE- ProRule:PRU00288}.
Similarity	Contains 2 PH domains. {ECO:0000255\|PROSITE- ProRule:PRU00145}.
Subcellular Location	Cytoplasm {ECO:0000269\|PubMed:14690521}. Cell membrane {ECO:0000269\|PubMed:14690521}. Note=Constitutively associated with the plasma membrane. Excluded from the nucleus.
Tissue Specificity	Highly expressed in placenta, spleen, kidney, skeletal muscle and adrenal gland. Weakly expressed in thyroid, liver, heart, lung, small intestine, peripheral blood leukocytes. Not detected in spinal cord, brain, stomach, trachea, colon, lymph node and bone marrow. {ECO:0000269\|PubMed:14690521}.