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MT001183

UniProt Annotations

Entry Information

Gene Name	acyl-CoA thioesterase 13
Protein Entry	ACO13_HUMAN
UniProt ID	Q9NPJ3
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NPJ3-1; Sequence=Displayed; Name=2; IsoId=Q9NPJ3-2; Sequence=VSP_046101; Note=No experimental confirmation available.;
Biophysicochemical Properties	Kinetic parameters: KM=4.9 uM for n-decanoyl-CoA {ECO:0000269\|PubMed:19170545}; KM=26 uM for n-octanoyl-CoA {ECO:0000269\|PubMed:19170545}; KM=5 uM for myristoyl-CoA {ECO:0000269\|PubMed:19170545}; KM=9 uM for palmitoyl-CoA {ECO:0000269\|PubMed:19170545}; KM=9 uM for oleoyl-CoA {ECO:0000269\|PubMed:19170545}; KM=10 uM for 3,4-dihydroxyphenylacetyl-CoA {ECO:0000269\|PubMed:19170545}; KM=40 uM for 3-hydroxyphenylacetyl-CoA {ECO:0000269\|PubMed:19170545};
Function	Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3- hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis (By similarity). {ECO:0000250}.
Similarity	Belongs to the thioesterase PaaI family. {ECO:0000305}.
Subcellular Location	Cytoplasm, cytosol {ECO:0000250}. Mitochondrion {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=During interphase, found both in the nucleus and in the cytoplasm. At mitosis, localizes to the spindle. Colocalizes with tubulin (By similarity). {ECO:0000250}.
Subunit	Homotetramer. {ECO:0000269\|PubMed:16934754, ECO:0000269\|PubMed:19170545}.