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MT001189

UniProt Annotations

Entry Information

Gene Name	cysteine conjugate-beta lyase 2
Protein Entry	KAT3_HUMAN
UniProt ID	Q6YP21
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6YP21-1; Sequence=Displayed; Name=2; IsoId=Q6YP21-2; Sequence=VSP_025603, VSP_025604; Note=No experimental confirmation available.; Name=3; IsoId=Q6YP21-3; Sequence=VSP_042841;
Catalytic Activity	An L-cysteine-S-conjugate + H(2)O = RSH + NH(3) + pyruvate.
Catalytic Activity	L-kynurenine + 2-oxoglutarate = 4-(2- aminophenyl)-2,4-dioxobutanoate + L-glutamate.
Catalytic Activity	L-kynurenine + glyoxylate = 4-(2-aminophenyl)- 2,4-dioxobutanoate + glycine.
Caution	The first non-coding exon of CCBL2 is in common with that of RBMXL1. {ECO:0000305}.
Cofactor	Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence={ECO:0000250};
Function	Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). May catalyze the beta-elimination of S-conjugates and Se- conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity). Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2- oxoglutarate as amino group acceptor (in vitro) (By similarity). {ECO:0000250}.
Sequence Caution	Sequence=AAC72959.1; Type=Frameshift; Positions=336; Evidence={ECO:0000305}; Sequence=AAH00819.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAG29278.1; Type=Frameshift; Positions=336; Evidence={ECO:0000305}; Sequence=CAI21695.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI21696.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41339.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41340.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Similarity	Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. {ECO:0000305}.
Subunit	Homodimer. {ECO:0000250}.