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MT001195

UniProt Annotations

Entry Information

Gene Name	3-hydroxybutyrate dehydrogenase, type 2
Protein Entry	BDH2_HUMAN
UniProt ID	Q9BUT1
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9BUT1-1; Sequence=Displayed; Name=2; IsoId=Q9BUT1-2; Sequence=VSP_015859; Name=3; IsoId=Q9BUT1-3; Sequence=VSP_039781;
Biophysicochemical Properties	Kinetic parameters: KM=60 uM for NAD {ECO:0000269\|PubMed:16380372}; KM=10 mM for R-hydroxybutyrate {ECO:0000269\|PubMed:16380372}; Vmax=82 nmol/min/mg enzyme (at 30 degrees Celsius) {ECO:0000269\|PubMed:16380372}; pH dependence: Optimum pH is 7.5-9.0. {ECO:0000269\|PubMed:16380372};
Catalytic Activity	(R)-3-hydroxybutanoate + NAD(+) = acetoacetate + NADH.
Function	Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity). {ECO:0000250}.
Pathway	Siderophore biosynthesis.
Similarity	Belongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.
Subcellular Location	Cytoplasm {ECO:0000269\|PubMed:16380372}.
Subunit	Homotetramer. {ECO:0000269\|PubMed:16380372}.