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MT001204

Record overview

MITO IDMT001204
Gene ID56997
SpeciesHomo sapiens (Human)
Gene NameaarF domain containing kinase 3
Gene SymbolADCK3
SynonymsCOQ8; ARCA2; CABC1; SCAR9; COQ10D4;
Alternate nameschaperone activity of bc1 complex-like, mitochondrial; coenzyme Q8 homolog; aarF domain-containing protein kinase 3; chaperone, ABC1 activity of bc1 complex homolog;
Chromosome1
Map Location1q42.13
EC Number2.7.11.-
SummaryThis gene encodes a mitochondrial protein similar to yeast ABC1, which functions in an electron-transferring membrane protein complex in the respiratory chain. It is not related to the family of ABC transporter proteins. Expression of this gene is induced by the tumor suppressor p53 and in response to DNA damage, and inhibiting its expression partially suppresses p53-induced apoptosis. Alternatively spliced transcript variants have been found; however, their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for ADCK3

Proteins

chaperone activity of bc1 complex-like, mitochondrial
Refseq ID:NP_064632
Protein GI:34147522
UniProt ID:Q8NI60
mRNA ID:NM_020247
Length:647
RefSeq Status:
MAAILGDTIMVAKGLVKLTQAAVETHLQHLGIGGELIMAARALQSTAVEQIGMFLGKVQGQDKHEEYFAENFGGPEGEFHFSVPHAAGASTDFSSASAPD
QSAPPSLGHAHSEGPAPAYVASGPFREAGFPGQASSPLGRANGRLFANPRDSFSAMGFQRRFFHQDQSPVGGLTAEDIEKARQAKARPENKQHKQTLSEH
ARERKVPVTRIGRLANFGGLAVGLGFGALAEVAKKSLRSEDPSGKKAVLGSSPFLSEANAERIVRTLCKVRGAALKLGQMLSIQDDAFINPHLAKIFERV
RQSADFMPLKQMMKTLNNDLGPNWRDKLEYFEERPFAAASIGQVHLARMKGGREVAMKIQYPGVAQSINSDVNNLMAVLNMSNMLPEGLFPEHLIDVLRR
ELALECDYQREAACARKFRDLLKGHPFFYVPEIVDELCSPHVLTTELVSGFPLDQAEGLSQEIRNEICYNILVLCLRELFEFHFMQTDPNWSNFFYDPQQ
HKVALLDFGATREYDRSFTDLYIQIIRAAADRDRETVRAKSIEMKFLTGYEVKVMEDAHLDAILILGEAFASDEPFDFGTQSTTEKIHNLIPVMLRHRLV
PPPEETYSLHRKMGGSFLICSKLKARFPCKAMFEEAYSNYCKRQAQQ