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MT001205

UniProt Annotations

Entry Information

Gene Name	ACN9 homolog (S. cerevisiae)
Protein Entry	SDHF3_HUMAN
UniProt ID	Q9NRP4
Species	Human

Comments

Comment type	Description
Function	Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1. {ECO:0000250\|UniProtKB:Q04401, ECO:0000250\|UniProtKB:Q8SZ16}.
Similarity	Belongs to the complex I LYR family. SDHAF3 subfamily. {ECO:0000305}.
Subcellular Location	Mitochondrion matrix {ECO:0000250\|UniProtKB:Q04401}.
Subunit	Interacts with SDHB within an SDHA-SDHB subcomplex. {ECO:0000250\|UniProtKB:Q04401}.