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MT001207

UniProt Annotations

Entry Information

Gene Name	cytokine induced apoptosis inhibitor 1
Protein Entry	CPIN1_HUMAN
UniProt ID	Q6FI81
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6FI81-1; Sequence=Displayed; Name=2; IsoId=Q6FI81-2; Sequence=VSP_012360; Note=No experimental confirmation available.; Name=3; IsoId=Q6FI81-3; Sequence=VSP_012361;
Cofactor	Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:49601; Evidence={ECO:0000255\|HAMAP-Rule:MF_03115, ECO:0000269\|PubMed:21700214, ECO:0000269\|PubMed:23596212}; Note=Binds 1 [2Fe-2S] cluster per subunit. {ECO:0000255\|HAMAP- Rule:MF_03115, ECO:0000269\|PubMed:21700214, ECO:0000269\|PubMed:23596212};
Domain	The C-terminal domain binds one 2Fe-2S iron-sulfur cluster but is otherwise mostly in an intrinsically disordered conformation.
Domain	The N-terminal domain has structural similarity with S- adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. {ECO:0000269\|PubMed:21700214}.
Domain	The twin Cx2C motifs are involved in the recognition by the mitochondrial CHCHD4/MIA40-GFER/ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.
Function	Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity). Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Electrons are transferred to the Fe-S cluster from NADPH via the FAD- and FMN-containing protein NDOR1. {ECO:0000250, ECO:0000269\|PubMed:23596212}.
Interaction	O76003:GLRX3; NbExp=3; IntAct=EBI-750511, EBI-374781;
Miscellaneous	'Ana-mors-in' means 'anti-death molecule' in Latin.
Sequence Caution	Sequence=AAC24312.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Similarity	Belongs to the anamorsin family. {ECO:0000255\|HAMAP- Rule:MF_03115}.
Subcellular Location	Cytoplasm. Nucleus. Mitochondrion. Mitochondrion intermembrane space {ECO:0000305}. Note=Imported into mitochondria (in vitro).
Subunit	Monomer. Interacts with NDOR1; its oxidized form can be reduced by NDOR1. Interacts with CHCHD4 and may be a substrate for CHCHD4 chaperone activity. {ECO:0000255\|HAMAP-Rule:MF_03115, ECO:0000269\|PubMed:21700214, ECO:0000269\|PubMed:23596212}.
Tissue Specificity	Ubiquitously expressed. Highly expressed in heart, liver and pancreas. {ECO:0000269\|PubMed:14970183}.