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MT001245

UniProt Annotations

Entry Information

Gene Name	dual specificity phosphatase 21
Protein Entry	DUS21_HUMAN
UniProt ID	Q9H596
Species	Human

Comments

Comment type	Description
Catalytic Activity	[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
Catalytic Activity	Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. {ECO:0000255\|PROSITE-ProRule:PRU10044}.
Function	Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine.
Similarity	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. {ECO:0000305}.
Similarity	Contains 1 tyrosine-protein phosphatase domain. {ECO:0000305}.
Subcellular Location	Cytoplasm {ECO:0000269\|PubMed:12408986}. Nucleus {ECO:0000269\|PubMed:12408986}. Mitochondrion inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Matrix side {ECO:0000250}.
Tissue Specificity	Expressed in testis. {ECO:0000269\|PubMed:12408986}.