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MT001263

UniProt Annotations

Entry Information

Gene Name	acyl-CoA binding domain containing 3
Protein Entry	GCP60_HUMAN
UniProt ID	Q9H3P7
Species	Human

Comments

Comment type	Description
Domain	The GOLD domain is essential for giantin binding.
Function	Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi. Involved in hormone-induced steroid biosynthesis in testicular Leydig cells (By similarity). {ECO:0000250}.
Interaction	O91464:- (xeno); NbExp=21; IntAct=EBI-1791792, EBI-7587528; Q9UBF8:PI4KB; NbExp=4; IntAct=EBI-1791792, EBI-1053214; Q8BHN0:Ppm1l (xeno); NbExp=3; IntAct=EBI-1791792, EBI-7970002;
Similarity	Contains 1 ACB (acyl-CoA-binding) domain. {ECO:0000255\|PROSITE-ProRule:PRU00573}.
Similarity	Contains 1 GOLD domain. {ECO:0000255\|PROSITE- ProRule:PRU00096}.
Subcellular Location	Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Mitochondrion {ECO:0000250}. Note=Also mitochondrial (via its interaction with PBR). {ECO:0000250}.
Subunit	Interacts with the C-terminal cytoplasmic domain of giantin/GOLGB1. Interacts with PBR and PKA regulatory subunit RI- alpha. Does not interact with PKA regulatory subunit RI-beta nor PKA regulatory subunit RII-alpha (By similarity). {ECO:0000250}.
Tissue Specificity	Ubiquitous, with highest expression in testis and ovary. {ECO:0000269\|PubMed:11590181}.