MitoProteome Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins

MT001267

UniProt Annotations

Entry Information

Gene Name	ceramide kinase
Protein Entry	CERK1_HUMAN
UniProt ID	Q8TCT0
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8TCT0-1; Sequence=Displayed; Name=2; IsoId=Q8TCT0-2; Sequence=VSP_056944; Note=No experimental confirmation available;
Biophysicochemical Properties	pH dependence: Optimum pH is 6.0-7.5.;
Catalytic Activity	ATP + ceramide = ADP + ceramide 1-phosphate.
Cofactor	Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
Cofactor	Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Enzyme Regulation	Inhibited by sulfatide. {ECO:0000269\|PubMed:19168031}.
Function	Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides. {ECO:0000269\|PubMed:19168031}.
Similarity	Contains 1 DAGKc domain. {ECO:0000255\|PROSITE- ProRule:PRU00783}.
Subcellular Location	Cytoplasm {ECO:0000269\|PubMed:19168031}. Membrane {ECO:0000269\|PubMed:19168031}; Peripheral membrane protein {ECO:0000269\|PubMed:19168031}.
Tissue Specificity	High level expression in heart, brain, skeletal muscle, kidney and liver; moderate in peripheral blood leukocytes and thymus; very low in spleen, small intestine, placenta and lung.