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MT001294

UniProt Annotations

Entry Information

Gene Name	caprin family member 2
Protein Entry	CAPR2_HUMAN
UniProt ID	Q6IMN6
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=9; Name=1 {ECO:0000269\|PubMed:16541075}; IsoId=Q6IMN6-1; Sequence=Displayed; Note=No experimental confirmation available. {ECO:0000305}; Name=2 {ECO:0000269\|PubMed:14593112}; Synonyms=EEG-1L {ECO:0000269\|PubMed:14593112}; IsoId=Q6IMN6-2; Sequence=VSP_052536, VSP_027920; Name=3 {ECO:0000269\|PubMed:15489334}; IsoId=Q6IMN6-3; Sequence=VSP_027920, VSP_052538, VSP_052539; Note=No experimental confirmation available. {ECO:0000305}; Name=4 {ECO:0000269\|PubMed:14702039}; IsoId=Q6IMN6-4; Sequence=VSP_052531; Note=No experimental confirmation available. {ECO:0000305}; Name=5 {ECO:0000269\|PubMed:14593112}; Synonyms=EEG-1S {ECO:0000269\|PubMed:14593112}; IsoId=Q6IMN6-5; Sequence=VSP_052532, VSP_052533; Name=6 {ECO:0000269\|Ref.5}; IsoId=Q6IMN6-6; Sequence=VSP_052534, VSP_052535; Name=7; IsoId=Q6IMN6-7; Sequence=VSP_052537, VSP_052538, VSP_052539; Note=No experimental confirmation available. {ECO:0000305}; Name=9; IsoId=Q6IMN6-9; Sequence=VSP_027920; Note=No experimental confirmation available.; Name=10; IsoId=Q6IMN6-10; Sequence=VSP_043293, VSP_052537, VSP_052538, VSP_052539; Note=No experimental confirmation available. {ECO:0000305};
Developmental Stage	Expression is highly regulated during erythroid development with increased expression at the stage of differentiation associated with the onset of global nuclear condensation and reduced cell proliferation. {ECO:0000269\|PubMed:14593112}.
Function	May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons. Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation. May be involved in apoptosis. {ECO:0000269\|PubMed:14593112}.
Interaction	O75197:LRP5; NbExp=3; IntAct=EBI-6918449, EBI-2466421;
Sequence Caution	Sequence=AAK83153.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Similarity	Belongs to the caprin family. {ECO:0000305}.
Similarity	Contains 1 C1q domain. {ECO:0000255\|PROSITE- ProRule:PRU00368}.
Subcellular Location	Isoform 1: Cytoplasm.
Subcellular Location	Isoform 2: Mitochondrion. Cytoplasm. Note=Expressed throughout the cytoplasm.
Subcellular Location	Isoform 5: Mitochondrion. Note=Colocalizes with aggregated mitochondria.
Tissue Specificity	Detected in all tissues tested with highest levels of expression in brain and spleen. {ECO:0000269\|PubMed:14593112}.