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MT001299

UniProt Annotations

Entry Information

Gene Name	dual specificity phosphatase 26 (putative)
Protein Entry	DUS26_HUMAN
UniProt ID	Q9BV47
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BV47-1; Sequence=Displayed; Name=2; IsoId=Q9BV47-2; Sequence=VSP_026406;
Catalytic Activity	[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
Catalytic Activity	Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. {ECO:0000255\|PROSITE-ProRule:PRU10044}.
Function	Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK). {ECO:0000269\|PubMed:15796912, ECO:0000269\|PubMed:16581800, ECO:0000269\|PubMed:16924234, ECO:0000269\|PubMed:17001450}.
Interaction	P04637:TP53; NbExp=9; IntAct=EBI-2924519, EBI-366083;
Similarity	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. {ECO:0000305}.
Similarity	Contains 1 tyrosine-protein phosphatase domain. {ECO:0000305}.
Subcellular Location	Cytoplasm. Nucleus. Golgi apparatus.
Subunit	Interacts with HSF4. {ECO:0000269\|PubMed:16581800}.
Tissue Specificity	Brain. In the brain it is expressed ubiquitously except in the hippocampus. Expressed in embryonal cancers (retinoblastoma, neuroepithilioma and neuroblastoma) and in anaplatic thyroid cancer. {ECO:0000269\|PubMed:15796912, ECO:0000269\|PubMed:16581800, ECO:0000269\|PubMed:16924234, ECO:0000269\|PubMed:17001450}.