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MT001303

UniProt Annotations

Entry Information

Gene Name	autophagy related 9A
Protein Entry	ATG9A_HUMAN
UniProt ID	Q7Z3C6
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q7Z3C6-1; Sequence=Displayed; Name=2; IsoId=Q7Z3C6-2; Sequence=VSP_013396; Name=3; IsoId=Q7Z3C6-3; Sequence=VSP_013397, VSP_013398; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.;
Function	Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H. {ECO:0000269\|PubMed:16940348}.
Interaction	Q8NEM7-2:-; NbExp=8; IntAct=EBI-727146, EBI-7568679; Q9UHD2:TBK1; NbExp=2; IntAct=EBI-727146, EBI-356402;
Sequence Caution	Sequence=BAB13882.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15246.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB55119.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Similarity	Belongs to the ATG9 family. {ECO:0000305}.
Subcellular Location	Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Under amino acid starvation or rapamycin treatment, redistributes from a juxtanuclear clustered pool to a dispersed peripheral cytosolic pool. The starvation- induced redistribution depends on ULK1, ATG13, as well as SH3GLB1.
Subunit	Interacts with SUPT20H. {ECO:0000269\|PubMed:19893488}.