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MT001329

UniProt Annotations

Entry Information

Gene Name	agmatine ureohydrolase (agmatinase)
Protein Entry	SPEB_HUMAN
UniProt ID	Q9BSE5
Species	Human

Comments

Comment type	Description
Catalytic Activity	Agmatine + H(2)O = putrescine + urea. {ECO:0000269\|PubMed:11914032}.
Cofactor	Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000255\|PROSITE-ProRule:PRU00742};
Pathway	Amine and polyamine biosynthesis; putrescine biosynthesis via agmatine pathway; putrescine from agmatine: step 1/1.
Similarity	Belongs to the arginase family. Agmatinase subfamily. {ECO:0000255\|PROSITE-ProRule:PRU00742}.
Subcellular Location	Mitochondrion.
Tissue Specificity	Highly expressed in liver and kidney. Also found in skeletal muscle, fetal liver, brain, testis, skin and the gastrointestinal tract. Within brain, expression is higher in the cerebral cortex with lower levels in the medulla and spinal cord. {ECO:0000269\|PubMed:11804860, ECO:0000269\|PubMed:11914032}.