MitoProteome Database

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MT001347

UniProt Annotations

Entry Information

Gene Name	acyl-CoA synthetase family member 2
Protein Entry	ACSF2_HUMAN
UniProt ID	Q96CM8
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q96CM8-1; Sequence=Displayed; Name=2; IsoId=Q96CM8-2; Sequence=VSP_055804; Note=No experimental confirmation available.; Name=3; IsoId=Q96CM8-3; Sequence=VSP_055805; Note=No experimental confirmation available.; Name=4; IsoId=Q96CM8-4; Sequence=VSP_055803; Note=No experimental confirmation available.;
Function	Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation. {ECO:0000269\|PubMed:16380219, ECO:0000269\|PubMed:17762044}.
Induction	By PPARG. {ECO:0000269\|PubMed:16380219}.
Similarity	Belongs to the ATP-dependent AMP-binding enzyme family. {ECO:0000305}.
Subcellular Location	Mitochondrion {ECO:0000305}.