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MT001363

UniProt Annotations

Entry Information

Gene Name	acyl-CoA synthetase bubblegum family member 2
Protein Entry	ACBG2_HUMAN
UniProt ID	Q5FVE4
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q5FVE4-1; Sequence=Displayed; Name=2; IsoId=Q5FVE4-2; Sequence=VSP_030719; Note=No experimental confirmation available.; Name=3; IsoId=Q5FVE4-3; Sequence=VSP_030718; Note=No experimental confirmation available.; Name=4; IsoId=Q5FVE4-4; Sequence=VSP_030717; Note=No experimental confirmation available.;
Catalytic Activity	ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA. {ECO:0000269\|PubMed:16371355, ECO:0000269\|PubMed:16762313}.
Developmental Stage	Weakly or not expressed in fetal testis. Highly expressed in adult testis and moderately in elderly testis. {ECO:0000269\|PubMed:15685348}.
Function	Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Has increased ability to activate oleic and linoleic acid. May play a role in spermatogenesis.
Sequence Caution	Sequence=CAE12157.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Similarity	Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily. {ECO:0000305}.
Subcellular Location	Cytoplasm. Membrane; Peripheral membrane protein.
Tissue Specificity	Testis-specific. {ECO:0000269\|PubMed:15685348, ECO:0000269\|PubMed:16371355, ECO:0000269\|PubMed:16762313}.