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MT001384

UniProt Annotations

Entry Information

Gene Name	ATPase family, AAA domain containing 3B
Protein Entry	ATD3B_HUMAN
UniProt ID	Q5T9A4
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=AAA-TOB3l; IsoId=Q5T9A4-1; Sequence=Displayed; Name=2; IsoId=Q5T9A4-2; Sequence=VSP_015637, VSP_015640, VSP_015641, VSP_015642; Note=No experimental confirmation available.; Name=3; Synonyms=AAA-TOB3s; IsoId=Q5T9A4-3; Sequence=VSP_015638, VSP_015639;
Developmental Stage	Expressed in proliferating embryonic stem cells and down-regulated during differentiation. {ECO:0000269\|PubMed:22664726}.
Function	May play a role in a mitochondrial network organization typical for stem cells, characterized by reduced mitochondrial metabolism, low mtDNA copies and fragmentated mitochondrial network. may act by suppressing ATAD3A function, interfering with ATAD3A interaction with matrix nucleoid complexes. {ECO:0000269\|PubMed:22664726}.
Induction	Up-regulated by MYC. {ECO:0000269\|PubMed:16909202}.
Sequence Caution	Sequence=BAA86587.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Similarity	Belongs to the AAA ATPase family. {ECO:0000305}.
Subcellular Location	Mitochondrion inner membrane {ECO:0000269\|PubMed:16909202, ECO:0000269\|PubMed:18063578}; Peripheral membrane protein {ECO:0000269\|PubMed:16909202, ECO:0000269\|PubMed:18063578}. Note=Has been found to co-purify with nucleoids (PubMed:22453275). Since it does not face the mitochondrial matrix, the association with nucleoids could be mediated by ATAD3A. {ECO:0000269\|PubMed:22453275}.
Subunit	Forms heterooligomers with ATAD3A. Interacts with components of the mitochondrial ribosome, including MRPL11 and MRPS18B, and with other proteins involved in mitochondrial RNA metabolism, possibly via interaction with ATAD3A. Interacts with GADD45GIP1. {ECO:0000269\|PubMed:22453275, ECO:0000269\|PubMed:22664726}.
Tissue Specificity	Tends to be down-regulated in differentiated cells and re-expressed in pluripotent stem cells or cancer cells (at protein level). {ECO:0000269\|PubMed:16909202, ECO:0000269\|PubMed:22664726}.