MitoProteome Database

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MT001390

UniProt Annotations

Entry Information

Gene Name	acyl-CoA dehydrogenase family, member 11
Protein Entry	ACD11_HUMAN
UniProt ID	Q709F0
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q709F0-1; Sequence=Displayed; Name=2; IsoId=Q709F0-2; Sequence=VSP_021188; Name=3; IsoId=Q709F0-3; Sequence=VSP_021187;
Catalytic Activity	Acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor.
Cofactor	Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000269\|Ref.7};
Function	Acyl-CoA dehydrogenase, that exhibits maximal activity towards saturated C22-CoA. {ECO:0000269\|PubMed:21237683}.
Sequence Caution	Sequence=BAB14158.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Similarity	Belongs to the acyl-CoA dehydrogenase family. {ECO:0000305}.
Subcellular Location	Peroxisome {ECO:0000250}. Mitochondrion {ECO:0000269\|PubMed:21237683}. Note=Has been detected associated with mitochondrial membrane, but no matrix, in kidney and cerebellum, as well as in a neuroblastoma cell line, but not in skin fibroblasts, where it is observed in cytoplasmic vesicles (PubMed:21237683). No mitochondrial targeting signals could be predicted for any known isoform, including a putative isoform starting at Met-316. {ECO:0000269\|PubMed:21237683}.
Subunit	Homodimer. {ECO:0000269\|Ref.7}.
Tissue Specificity	Widely expressed with highest levels in brain followed by liver, heart and kidney. {ECO:0000269\|PubMed:21237683}.