MitoProteome Database

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MT001397

UniProt Annotations

Entry Information

Gene Name	alkB, alkylation repair homolog 7 (E. coli)
Protein Entry	ALKB7_HUMAN
UniProt ID	Q9BT30
Species	Human

Comments

Comment type	Description
Caution	Was initially reported to localize both in cytoplasm and nucleus (PubMed:17979886). However, it was later shown it localizes in mitochondrion (PubMed:23666923). The discrepancy is probably due to the use of a fusion protein with an N-terminal tag in the initial report (PubMed:17979886). {ECO:0000305\|PubMed:17979886, ECO:0000305\|PubMed:23666923}.
Cofactor	Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence={ECO:0000250}; Note=Binds 1 Fe(2+) ion per subunit. {ECO:0000250};
Function	Probable dioxygenase required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. Does not display DNA demethylase activity. Involved in fatty acid metabolism. {ECO:0000269\|PubMed:23666923}.
Similarity	Belongs to the alkB family. {ECO:0000305}.
Subcellular Location	Mitochondrion matrix {ECO:0000269\|PubMed:23666923}.
Tissue Specificity	Widely expressed, with highest expression in pancreas, followed by spleen, prostate, ovary and placenta. {ECO:0000269\|PubMed:17979886}.