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MT001399

UniProt Annotations

Entry Information

Gene Name	chromosome 9 open reading frame 89
Protein Entry	BINCA_HUMAN
UniProt ID	Q96LW7
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96LW7-1; Sequence=Displayed; Name=2; IsoId=Q96LW7-2; Sequence=VSP_014723; Note=Appears to be the dominant isoform in peripheral blood cell fractions. Contain a transmembrane helix.;
Function	Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner. {ECO:0000269\|PubMed:15637807}.
Similarity	Contains 1 CARD domain. {ECO:0000305}.
Subcellular Location	Isoform 1: Nucleus {ECO:0000269\|PubMed:23633586}. Note=Coexpression with BCL10 induced translocation from nucleus to cytosol.
Subcellular Location	Isoform 2: Endoplasmic reticulum membrane {ECO:0000269\|PubMed:23633586}; Single-pass membrane protein {ECO:0000269\|PubMed:23633586}. Mitochondrion membrane {ECO:0000269\|PubMed:23633586}; Single-pass membrane protein {ECO:0000269\|PubMed:23633586}.
Subunit	Associates with BCL10 by CARD-CARD interaction.
Tissue Specificity	Expressed in ovary, testis, placenta, skeletal muscle, kidney, lung, heart and liver (at protein level). Expressed in thymus and brain. {ECO:0000269\|PubMed:15637807}.