MitoProteome Database

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MT001405

UniProt Annotations

Entry Information

Gene Name	coiled-coil-helix-coiled-coil-helix domain containing 6
Protein Entry	MIC25_HUMAN
UniProt ID	Q9BRQ6
Species	Human

Comments

Comment type	Description
Function	Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. {ECO:0000269\|PubMed:22228767}.
Induction	Down-regulated following genotoxic stress. {ECO:0000269\|PubMed:22228767}.
Similarity	Belongs to the MICOS complex subunit Mic19 family. Metazoan Mic25 subfamily. {ECO:0000305}.
Similarity	Contains 1 CHCH domain. {ECO:0000305}.
Subcellular Location	Mitochondrion inner membrane {ECO:0000305\|PubMed:22228767}; Lipid-anchor {ECO:0000305\|PubMed:22228767}.
Subunit	Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27 and IMMT/MIC60. The complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2, and with HSPA9. Interacts with DISC1. {ECO:0000269\|PubMed:17624330, ECO:0000269\|PubMed:22228767}.